c-FLIP degradation mediates sensitization of pancreatic cancer cells to TRAIL-induced apoptosis by the histone deacetylase inhibitor LBH589.
Great efforts have been made to develop novel and efficacious therapeutics against pancreatic cancer to improve the treatment outcomes.Tumor-necrosis factor-related apoptosis-inducing ligand (TRAIL) is such a therapeutic cytokine with selective killing effect toward malignant Chemistry cells.However, some human pancreatic cancers are intrinsically